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Image Search Results
Journal: Nature Communications
Article Title: Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates
doi: 10.1038/s41467-020-17544-3
Figure Lengend Snippet: Littermate control (LMC), CRP, and INS2 Tg mice (CD45.2, Thy1.2) were irradiated and reconstituted with 1% OT-II (CD45.2, Thy1.1) and 99% WT (CD45.1, Thy1.2) bone marrow. The hematopoietic chimeras were analyzed 6-8 weeks post-irradiation. a Proportion of mature TCRβ hi CD4 + SP OT-II thymocytes among total live cells and absolute number of live CD4 + SP OT-II thymocytes. b Proportion of OT-II cells within the CD4 + T cell population in the peripheral lymph nodes. c Representative flow plots of CD25 and FoxP3 expression on OT-II T cells. d Proportion and absolute cell number of CD25 + Foxp3 + OT-II T cells in the thymus. e Proportion of CD25 + Foxp3 + OT-II T cells in the lymph nodes. (mean ± SEM, n = 17 LMC, 8 CRP, 10 INS2, from three independent experiments). All p -values indicated are calculated by Kruskal-Wallis test followed by Dunn’s post-hoc comparisons to LMC, two-sided. ** p < 0.01 relative to LMC. Source data are provided as a Source Data file.
Article Snippet: Six to twelve week-old male or female donor mice were injected i.p. with 100 μg
Techniques: Control, Irradiation, Expressing